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Kuwait detects first Omicron variant case in European man

Dr Abdullah Al-Sanad

By B Izzak & Agencies

KUWAIT: The health ministry announced yesterday that it has detected the first case of the new COVID-19 variant Omicron in a European man who arrived in Kuwait from an African country where Omicron cases had been reported. Health Ministry Spokesman Dr Abdullah Al-Sanad said the discovery came after authorities conducted sequencing tests that found the European man was infected with the Omicron variant.

He said the man has been placed in institutional quarantine since his arrival at Kuwait airport. The ministry did not say when the man arrived in the country and from which African nation he had come from. It did not also reveal his age or health condition. The pandemic situation in Kuwait has improved dramatically, as health authorities have recorded fewer than 40 cases a day since Oct 11 with a few deaths.

Meanwhile, two doses of the BioNTech and Pfizer coronavirus vaccine may not be enough to protect against the Omicron variant, the companies warned yesterday, but stressed it was “still effective” after a third jab. Omicron has caused global concern over signs that it can transmit faster than previous strains and fears that its multiple mutations could help it evade immune defenses provided by vaccines. No deaths have yet been associated with the variant.

In preliminary results published yesterday, Pfizer and BioNTech said their vaccine “is still effective in preventing COVID-19, also against Omicron, if it has been administered three times”. But they warned that “the Omicron variant is probably not sufficiently neutralized after two doses”. According to the early laboratory research using blood serum from vaccinated people, a booster third dose generated around the same level of antibodies against Omicron as is seen after a second dose with other variants.

Blood samples from people who had received two doses of the current vaccine showed on average a 25-fold reduction in neutralizing antibodies compared to the early strain of the virus, the companies said. But they added that another part of the immune response – from T cells – were probably still effective against the variant, adding that “vaccinated individuals may still be protected against severe forms of the disease”. Their results have not been peer reviewed.

The companies said that an Omicron-specific version of the anti-coronavirus vaccine, currently in development by BioNTech, would be available by March. “Although two doses of the vaccine may still offer protection against severe disease caused by the Omicron strain, it’s clear from these preliminary data that protection is improved with a third dose of our vaccine,” Pfizer Chief Executive Albert Bourla said in a statement.

The announcement comes after other preliminary results from a small study in South Africa suggested there was up to a forty-fold drop in the ability of the antibodies from the Pfizer-BioNTech vaccine to neutralize Omicron, compared to the earlier Beta variant. The results suggest “that there is definitely much less neutralization against Omicron compared to neutralization against the original strains that came out of Wuhan initially,” said Willem Hanekom, executive director of the Africa Health Research Institute, which carried out the study.

But he cautioned that it was important to be “extraordinarily careful” interpreting the results because they only reflect a laboratory setting. “What we need is real world results of what is happening out there,” he told AFP. Omicron counts more than 30 mutations on the spike protein that dots the surface of the coronavirus and allows it to invade cells.

Given the array of changes in this strain of the virus, Paul Moss, Deputy Head of the College of Medical and Dental Sciences at the University of Birmingham, said this kind of result “was not unexpected”. However he said “emerging evidence from booster vaccinations shows that they are capable of generating very high levels of antibody which should potentially still provide valuable protection against infection”.

The detection of the first Omicron cases two weeks ago coincided with jumping infection numbers across the world, and the variant added fuel to concerns about a global COVID resurgence. Dozens of nations have re-imposed border restrictions in response to the spread of the new virus variant and raised the possibility of a return of economically punishing lockdowns.

Scientists from the World Health Organization and the United States government told AFP this week the Omicron variant appeared to be no worse than other coronavirus strains but said more research was still necessary. Omicron has so far been found in 57 countries, the WHO said.

After the discovery of the Omicron variant, the Cabinet imposed a total ban on commercial flights from nine African countries where cases of the variant were announced. The government also barred the entry of people from those countries unless they had stayed for at least 14 days outside those countries. Dr Sanad assured the public that the health situation in the country is excellent but urged people to complete their vaccination doses. He also called on them to take the third booster dose to strengthen their immunity against COVID. – Agencies


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